Boston to South American cities from only $306 roundtrip

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Cheap flights from Boston to South American cities from only $306 roundtrip with Copa Airlines.

Fly to:
Quito: $306
Cartagena: $332
Georgetown: $399
Santa Cruz: $492

DEPART:
Boston, USA

ARRIVE:
Quito, Ecuador
Cartagena, Colombia
Georgetown, Guyana
Santa Cruz, Bolivia

RETURN:
Boston, USA

DATES:
Availability from September to November 2025

Example dates:

Boston – Quito: $306
6th-13th Oct
7th-14th Oct
8th-15th Oct
9th-16th Oct
13th-20th Oct
14th-21st Oct
15th-22nd Oct
16th-23rd Oct
11th-18th Nov
13th-20th Nov
18th-25th Nov

Boston – Cartagena: $332
18th-25th Sep
25th Sep – 2nd Oct
2nd-9th Oct
7th-14th Oct
9th-16th Oct
20th-27th Oct
21st-28th Oct
30th Oct – 6th Nov
10th-17th Nov
11th-18th Nov

Boston – Georgetown: $399
21st-28th Oct
22nd-29th Oct
29th Oct – 5th Nov
11th-18th Nov
18th-25th Nov

Boston – Santa Cruz: $492
5th-12th Sep
6th-13th Sep
15th-22nd Sep
17th-24th Sep
18th-25th Sep
22nd-29th Sep
24th Sep – 1st Oct
1st-8th Oct
3rd-10th Oct
4th-11th Oct
5th-12th Oct
6th-13th Oct
8th-15th Oct
10th-17th Oct
11th-18th Oct
12th-19th Oct
13th-20th Oct
14th-21st Oct
17th-24th Oct
18th-25th Oct
19th-26th Oct
20th-27th Oct
21st-28th Oct
22nd-29th Oct
23rd-30th Oct
24th-31st Oct
25th Oct – 1st Nov
26th Oct – 2nd Nov
27th Oct – 3rd Nov
28th Oct – 4th Nov
29th Oct – 5th Nov
30th Oct – 6th Nov
31st Oct – 7th Nov
3rd-10th Nov
4th-11th Nov
5th-12th Nov
6th-13th Nov
7th-14th Nov
8th-15th Nov
9th-16th Nov
10th-17th Nov
11th-18th Nov
12th-19th Nov
13th-20th Nov
14th-21st Nov
15th-22nd Nov
16th-23rd Nov
17th-24th Nov

and more…

STOPS:
Panama City

AIRLINES:
Copa Airlines